You can use Where to filter results.

Sql

Delete From Table_Name;
Where
    Column1=some_value
and
    Column2=some_another_value;

JsStore

var rowsDeleted = await connection.remove({
    from: "Table_Name",
    where: {
        column1: some_value,
        column2: some_another_value
    }
});
//results will contains no of rows deleted.
console.log(rowsDeleted);

Example